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- NIEUW: Imaging Genetics in ADHD
- Challenges and methods in developmental neuroimaging
- Imaging genetics in ADHD: A focus on cognitive control
- Magnetic Resonance Simulation Is Effective in Reducing Anxiety Related To Magnetic Resonance Scanning in Children
- Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation
- Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder
- Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Decit Hyperactivity Disorder
- A shift from diffuse to focal cortical activity with development
- What have we learned about cognitive development from neuroimaging?
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
- Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRI
- Differential Patterns of Striatal Activation in Young Children with and without ADHD
- The Effect of Preceding Context on Inhibition: An Event-Related fMRI Study
- Anatomical MRI of the Developing Human Brain: What Have We Learned?
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- NIEUW: Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography
- The neurobiology of repetitive behavior: Of mice...
- The neurobiology of repetitive behavior: ...and men
- Changes in the developmental trajectories of striatum in autism
- Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
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- Functional connectivity between cognitive control regions is sensitive to familial risk for ADHD
- Basic Impairments in Regulating the Speed-AccuracyTradeoff Predict Symptoms ofAttention-Deficit/Hyperactivity Disorder
- Familial vulnerability to ADHD affects activity in the cerebellum in addition to the prefrontal systems
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Niche Lab - Neuroimaging In Childhood
Progressive Structural Brain Changes During Development of Psychosis
Progressive Structural Brain Changes During Development of Psychosis
Tim B. Ziermans, Patricia F. Schothorst, Hugo G. Schnack, P. Cedric M. P. Koolschijn, Rene S. Kahn,
Herman van Engeland, and Sarah Durston
Background: Ultra-high risk (UHR) for psychosis has
been associated with widespread structural brain
changes in young adults. The onset of these changes
and their subsequent progression over time are not
well understood. Methods: Rate of brain change over
time was investigated in 43 adolescents at UHR for psychosis
compared with 30 healthy controls. Brain volumes
(total brain, gray matter, white matter [WM], cerebellum,
and ventricles), cortical thickness, and voxel-based
morphometry were measured at baseline and at followup
(2 y after baseline) and compared between UHR individuals
and controls. Post hoc analyses were done for
UHR individuals who became psychotic (N 5 8) and
those who did not (N 5 35). Results: UHR individuals
showed a smaller increase in cerebral WM over time
than controls and more cortical thinning in the left middle
temporal gyrus. Post hoc, a more pronounced decrease
over time in total brain and WM volume was
found for UHR individuals who became psychotic relative
to controls and a greater decrease in total brain
volume than individuals who were not psychotic. Furthermore,
UHR individuals with subsequent psychosis
displayed more thinning than controls in widespread
areas in the left anterior cingulate, precuneus, and
temporo-parieto-occipital area. Volume loss in the individuals
who developed psychosis could not be attributed
to medication use. Conclusion: The development of psychosis
during adolescence is associated with progressive
structural brain changes around the time of onset. These
changes cannot be attributed to (antipsychotic) medication
use and are therefore likely to reflect a pathophysiological
process related to clinical manifestation of
psychosis.
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Auteur
Naam Tim Ziermans
Functie Niche oud-NICHE-er
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