- NICHE - Research
- NICHE - The lab
- We are NICHE
- Sarah
- Imaging genetics in ADHD: A focus on cognitive control
- Magnetic Resonance Simulation Is Effective in Reducing Anxiety Related To Magnetic Resonance Scanning in Children
- Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation
- Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder
- Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Decit Hyperactivity Disorder
- A shift from diffuse to focal cortical activity with development
- What have we learned about cognitive development from neuroimaging?
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
- Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRI
- Differential Patterns of Striatal Activation in Young Children with and without ADHD
- The Effect of Preceding Context on Inhibition: An Event-Related fMRI Study
- Anatomical MRI of the Developing Human Brain: What Have We Learned?
- Marieke
- Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography
- The neurobiology of repetitive behavior: Of mice...
- The neurobiology of repetitive behavior: ...and men
- Changes in the developmental trajectories of striatum in autism
- Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
- Tamar
- Patrick
- Inhibitory Performance, ResponseSpeed, Intraindividual Variability, and Response Accuracy in ADHD
- Decreased Frontostriatal Microstructural Organization in Attention Deficit/Hyperactivity Disorder
- Prenatal exposure to cigarette smoke or alcohol and cerebellum volume in attention-deficit/hyperactivity disorder and typical development
- Differential Brain Development with Low and High IQ in Attention-Deficit/Hyperactivity Disorder
- Janna
- Sarai
- Sanne
- Dienke
- Lara
- Branko
- Juliette
- Rosanne
- Nieke
- Lizanne
- Sanne
- Kelli
- Sara
- Sarah
- Alumni
- We are NICHE
- Library
- News
- Jobs/ internships
- Ask Niche
- Symposium
Niche Lab - Neuroimaging In Childhood
Inhibitory Performance, ResponseSpeed, Intraindividual Variability, and Response Accuracy in ADHD
Inhibitory Performance, ResponseSpeed, Intraindividual Variability, and Response Accuracy in ADHD
Patrick de Zeeuw, Cornelieke Aarnoudse-Moens, Joyce Bijlhout, Claudia König, Annebeth Post Uiterweer, Alky Papanikolau, Caecilia Hoogenraad, Lieke Imandt, Debbie de Been, Joseph A. Sergeant and Jaap Oosterlaan - Journal of the American Academy of Child and Adolescent Psychiatry 2008 vol. 47 (7) pp. 808-16
Objective: To determine the potential of inhibitory performance, response speed, and response accuracy and variability, measures central to the conceptualization of attention-deficit/hyperactivity disorder (ADHD), in distinguishing children with ADHD from healthy controls (HCs).
Method: The stop signal paradigm was administered to 38 children with ADHD and 31 NCs. The stop signal reaction time (SSRT), mean reaction time (MRT), intraindividual coefficient of variation (ICV), and number of errors were used to predict diagnostic status.
Results: Univariate tests showed that the ADHD group performed worse than NCs on all of the dependent variables. Exploratory univariate analyses showed that oppositional defiant disorder comorbidity and ADHD type did not influence results except for the ICV, the effect for this variable (more variability in the ADHD group) being less pronounced for the Predominantly Inattentive type than for the Hyperactive-Impulsive and Combined types. A logistic regression model of the MRT, ICV, and number of errors combined showed best predictive performance, with the MRT contributing the most to group classification (56% of the variance). The final model (MRT, ICV, and number of errors) predicted 87% of the sample in the correct diagnostic category. Operating characteristics showed excellent sensitivity and specificity of 89.5% and 83.9%, respectively.
Conclusions: Our results contrast with theoretical accounts emphasizing inhibitory control as the pivotal measure characterizing cognitive performance in ADHD. Results are discussed in the context of a delay aversion perspective of ADHD.
Meer weten?
Download het
onderzoek hier!
Auteur
Naam Patrick de Zeeuw
Functie Niche PhD student
Made by: The Projects