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- Imaging genetics in ADHD: A focus on cognitive control
- Magnetic Resonance Simulation Is Effective in Reducing Anxiety Related To Magnetic Resonance Scanning in Children
- Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation
- Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder
- Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Decit Hyperactivity Disorder
- A shift from diffuse to focal cortical activity with development
- What have we learned about cognitive development from neuroimaging?
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
- Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRI
- Differential Patterns of Striatal Activation in Young Children with and without ADHD
- The Effect of Preceding Context on Inhibition: An Event-Related fMRI Study
- Anatomical MRI of the Developing Human Brain: What Have We Learned?
- Marieke
- Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography
- The neurobiology of repetitive behavior: Of mice...
- The neurobiology of repetitive behavior: ...and men
- Changes in the developmental trajectories of striatum in autism
- Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
- Tamar
- Patrick
- Inhibitory Performance, ResponseSpeed, Intraindividual Variability, and Response Accuracy in ADHD
- Decreased Frontostriatal Microstructural Organization in Attention Deficit/Hyperactivity Disorder
- Prenatal exposure to cigarette smoke or alcohol and cerebellum volume in attention-deficit/hyperactivity disorder and typical development
- Differential Brain Development with Low and High IQ in Attention-Deficit/Hyperactivity Disorder
- Janna
- Sarai
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Niche Lab - Neuroimaging In Childhood
Psychosis
The third group that we are working on within NICHE, is young adolescents at risk for psychosis. The studies in this research line are part of the Dutch Prediction of Psychosis (DUPS) study. Main investigator on this project is Sanne de Wit, she is continuing the work of Tim Ziermans (now a NICHE alumnus).
Within the DUPS project, structural MRI data, physiological measures (ERP, EMG and EOP data) and symptom measures are acquired for adolescents at risk of developing psychosis and matched controls. The aim is to chart the development of these neurobiological correlates and relate them to the clinical manifestation of psychosis. With this information, we hope to be able to identify neurobiological predictors for developing psychosis in the long run.
So far, the baseline data showed that there were no gross structural brain abnormalities in young adolescents at risk compared to typical controls (see Tim's page for this publication).
At the neurophysiological level, four classical schizophrenia markers were examined. Only prepulse inhibition (PPI) was found to discriminate between at-risk adolescents and controls. These data suggest that neurobiological markers of schizophrenia that are also present (to a lesser extent) in adult at-risk patients, are relatively unaffected in young adolescents at risk.
Tim will defend his PhD-thesis on September 30, 2010. Sanne started her project in September 2009 and is expected to finish in 2013.
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